Top team Uruguay (0-1-0, 0 points) will look to endure the absence of main man Luis Suárez for the second straight game in the 2016 Copa América Centenario as they face lowly team Venezuela (1-0-0, 3 points), who pulled off an upset win in their opening match, at the Lincoln Financial Field in Philadelphia on Thursday, June 9.
FC Barcelona star Suárez missed Uruguay's opener against Mexico on Sunday due to a hamstring injury he suffered in Barça's 2-0 Copa del Rey victory over Sevilla last month. He is expected to miss again this game against Venezuela as his leg has still not completely recovered.
La Celeste was shell-shocked by El Tri as a result, 1-3, at the University of Phoenix Stadium in Glendale, Goal reported.
Things did not look good from the beginning for head coach Óscar Tabárez's side as aside from the speakers erroneously playing Chile's national anthem before kickoff, the opening score was also brought by an own goal by wingback Alvaro Pereira right at the fourth minute of the match.
They were able to fend off Mexico's attacks from then on, but then they were reduced to ten men after Matias Vecino was sent off at the 45th after getting booked for a second yellow.
Team captain Diego Godin of Atletico Madrid was able to equalize the game at the 74th after Mexico's Andres Guardado was also sent off one minute prior.
However, two goals from El Tri, courtesy of Rafael Marquez and Hector Herrera, in the final five minutes took the game away from the Uruguayans.
Meanwhile, Venezuela stunned Jamaica, 1-0, in Group C's opening match at the Soldier Field in Chicago also on Sunday, via Daily Mail Online.
Torino striker Josef Martinez scored the winning goal of the contest at the 15th minute as La Vinotinto grabbed a crucial three points in the overall standings.
They are still the underdogs going into this game versus Los Charrúas, but as their first game performance had shown, anything could happen.
The predicted result is a 2-0 bounce back win for Uruguay.
Uruguay starting lineup (4-4-1-1 formation): Muslera; M. Pereira, Gimenez, Godin, A. Pereira; Sanchez, Ramirez, Arevalo, Rolan; Lodeiro; Cavani
Venezuela starting lineup (4-2-3-1 formation): Hernandez; Rosales, Angel, Vizcarrondo, Feltscher; Rincon, Figuera; Guerra, Martinez, Seijas; Rondón