Last season's Segunda División winner Real Betis (4-4-3, 15 points) will host one of the 2015-2016 La Liga season's top contenders, Atletico Madrid (7-2-2, 23 points), at their home field of Estadio Benito Villamarín on Sunday, November 22nd.
Los Béticos is competing quite well for a newly-promoted squad, winning three of their last six matches while drawing one and losing two.
Pepe Mel's boys are coming off a tough 1-0 victory over lowly squad Malaga at the La Rosaleda Stadium on November 7th before the international break, as reported by ESPN.
Spanish striker Rubén Castro scored the lone goal of the match four minutes after the hour mark to give Betis another three points in the overall standings.
Atletico Madrid continues to be a prime candidate to dethrone Barcelona as it presently hovers at the third spot in the league table behind the defending champions and perennial contenders Real Madrid.
Atleti won their most recent match against Sporting Gijon, 1-0, at the Vicente Calderón Stadium on November 8th before taking their international break as well, via SkySports.
Star forward Antoine Griezmann saved the win for Diego Simeone's side with a strike during injury time.
With the win, Los Colchoneros extended their unbeaten run to five games heading into this match with Betis in which they are favored to win by at least two goals.
The prediction is a 2-0 victory for Atletico Madrid.
Real Betis starting lineup (4-2-3-1 formation): Adan; Piccinini, González, Westermann, Varela; Digard, Petros; Cejudo, van der Vaart, Joaquin; Castro
Atletico Madrid starting lineup (4-4-2 formation): Oblak; Juanfran, Savic, Godin, Luis; Koke, Fernandez, Mendes, Carrasco; Martinez, Griezmann