Struggling team Hamburger SV (4-5-3, 15 points) will take on powerhouse squad Borussia Dortmund (9-1-2, 29 points) on November 20, Friday at the Volksparkstadion for a 2015-2016 Bundesliga season matchup.
Hamburg is coming off a 1-1 draw with newly-promoted club Darmstadt 98 at the Merck-Stadion am Böllenfalltor on November 7, as per ESPN.
Die Rothosen forward Pierre-Michel Lasogga pierced the goal first with a penalty kick at the 29th minute of the match, but Die Lilien midfielder Marcel Heller leveled it two minutes after halftime as both teams settled for the tie.
Bruno Labbadia's boys have won only once in their last six outings and they will try to score an upset against top contender Borussia Dortmund in this match.
Die Borussen won their fourth straight game after a 3-2 escape against top five team Schalke at the Signal Iduna Park on November 8, via SkySports.
Der BVB's Japanese midfielder Shinji Kagawa opened the scoring at the 30th minute which was equalized just three minutes later by Schalke striker and vice-captain Klaas-Jan Huntelaar.
Matthias Ginter and Pierre-Emerick Aubameyang scored goals at the 43rd and 47th to give Thomas Tuchel's side a commanding 3-1 lead going into the home stretch.
Huntelaar managed to score another one at the 71st for the final count as Die Königsblauen failed on a comeback attempt.
BVB is projected to rout Hamburg on the road this weekend to extend their winning streak to five games.
The prediction is a 4-0 romp for Borussia Dortmund.
Hamburg starting lineup (4-4-2 formation): Adler; Sakai, Djourou, Spahic, Ostrzolek; Muller, Diaz, Holtby, Gregoritsch; Lasogga, Schipplock
Borussia Dortmund starting lineup (4-3-3 formation): Burki; Ginter, Papastathopoulos, Hummels, Schmelzer; Gundogan, Weigl, Kagawa; Castro, Aubameyang, Mkhitaryan