• L-R) Actors Jared Padalecki, Jensen Ackles, Misha Collins, and Mark Sheppard attend the 'Supernatural' Special Video Presentation And Q&A during Comic-Con International 2016 at San Diego Convention Center on July 24, 2016 in San Diego, California.

L-R) Actors Jared Padalecki, Jensen Ackles, Misha Collins, and Mark Sheppard attend the 'Supernatural' Special Video Presentation And Q&A during Comic-Con International 2016 at San Diego Convention Center on July 24, 2016 in San Diego, California. (Photo : (Photo by Kevin Winter/Getty Images) )

"Supernatural" Season 12 episode 1 is here. The highly anticipated segment starring Jensen Ackles as Dean and Jared Padalecki as Sam is titled "Keep Calm and Carry On" and it will see the much awaited Winchester reunion and Sam and Dean deal with the new problem, Men of Letters.  Here are the detailed spoilers for episode 12X01. Read on to find out what happens next. Also, find out where to watch the premiere online via live stream.

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[Spoiler alert! This article contains spoilers for "Supernatural" Season 12 episode 1 (premiere) "Keep Calm and Carry On." Do not read further if you don't wish to know more about it.]

"Supernatural" Season 11 finale ended with Lucifer and Amara's reunion. Lady Antonio Bevell of the London Chapter of the Men of Letters arrive in search of Sam, who she reveals must be punished for his acts. Meanwhile, Dean meets his resurrected mother, Mary Winchester.

Moving on "Supernatural" Season 12 episode 1 "Keep Calm and Carry On." According to Spoilers Guide's description for the premiere segment, the show will revolve around Dean and Mary's reunion and Sam's encounter with Lady Antonio.

It is said that the unexpected resurrection of his mother will leave Dean overwhelmed. The return of his mother will have a strong emotional effect on Dean. "Supernatural" Season 12 opener will feature Dean and Mary's first interaction after Mary's resurrection.

In an interview with Entertainment Weekly, "Supernatural" showrunner Andrew Dabb revealed that Mary's return will not shift the focus from Sam and Dean but see how she does she affect Dean and Sam. At the same time, she and Castiel for a "really interesting friendship." She is going to play a "nice pivot point" for the characters.

In addition, "Supernatural" Season 12 episode 1 will see Sam's life hang in the balance after he was shot by Lady Antonio. Will Sam survive is not the question, but will he be able to escape the punishment for his actions?

A promo video for "Supernatural" Season 12 teases an intense premiere. Scroll down to watch it online.

"Supernatural" Season 12 episode 1 airs Oct. 13 at 9:00 pm on CW. Fans can also watch the premiere online via live stream on cwtv.com after its television broadcast. More spoilers and updates are expected soon.