• Barcelona's Big Three of (from L to R) Luis Suárez, Neymar, and Lionel Messi.

Barcelona's Big Three of (from L to R) Luis Suárez, Neymar, and Lionel Messi. (Photo : Getty Images)

Valencia CF (5-4-4, 19 points) is on the verge of a two-game losing slide as it faces 2015-2016 La Liga league leaders FC Barcelona (11-2-0, 33 points) and its unstoppable trio of Lionel Messi, Neymar, and Luis Suárez at the Mestalla Stadium on December 5, Saturday.

Los Che dropped a sorry 0-1 decision to Sevilla at the Estadio Ramón Sánchez Pizjuán on Sunday as defender João Cancelo and midfielder Javi Fuego were sent off at the 35th and 78th minutes respectively, as reported by Goal.

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In between the two red cards was the score by Sevilla defender Sergio Escudero five minutes into the second half to take away the three points from Valencia.

Meanwhile, Barcelona welcomed back their main man Messi with an astounding 4-0 victory over Real Sociedad at the Camp Nou last Saturday, as per SkySports.

Neymar scored a double while Suárez and Messi each had a goal on the way to the lopsided win against the Txuriurdin.

It was actually Messi's second game back as he came off the bench but did not score during Barça's famed 4-0 conquest of Real Madrid during their El Clásico match on November 21.

Neymar and Suárez are leading the club in scoring this season and with the return of Messi, Luis Enrique's squad looked as invincible as ever.

The predicted result is another 4-0 blowout for Barcelona with Messi this time scoring a brace.

Valencia starting lineup (4-5-1 formation): Ryan; Vezo, Santos, Abdennour, Gaya; Perez, Feghouli, Danilo, Parejo, Mina; Alcacer

Barcelona starting lineup (4-3-3 formation): Bravo; Alves, Pique, Mascherano, Mathieu; Rakitic, Busquets, Iniesta; Messi, Suárez, Neymar